Ambulatory Pediatrics
Volume 7, Issue 5 , Pages 383-389 , September 2007

Adverse Drug Events in Pediatric Outpatients

  • Rainu Kaushal, MD, MPH

      Affiliations

    • Division of General Internal Medicine, Brigham and Women's Hospital, Boston, Mass
    • Department of Public Health, Weill Medical College of Cornell University, New York, NY
    • Department of Medicine, Children's Hospital Boston, Boston, Mass
    • Harvard Medical School, Boston, Mass
    • Corresponding Author InformationAddress correspondence to Rainu Kaushal, MD, MPH, Department of Public Health, Weill Medical College, 411 East 69th Street KB 312, NY, NY 10021.
    • ,
  • Donald A. Goldmann, MD

      Affiliations

    • Department of Medicine, Children's Hospital Boston, Boston, Mass
    • Harvard Medical School, Boston, Mass
    • Institute for Healthcare Improvement, Cambridge, Mass
    • ,
  • Carol A. Keohane, RN, BSN

      Affiliations

    • Division of General Internal Medicine, Brigham and Women's Hospital, Boston, Mass
    • Harvard Medical School, Boston, Mass
    • ,
  • Melissa Christino, AB

      Affiliations

    • Division of General Internal Medicine, Brigham and Women's Hospital, Boston, Mass
    • Harvard Medical School, Boston, Mass
    • ,
  • Melissa Honour, MPH

      Affiliations

    • Division of General Internal Medicine, Brigham and Women's Hospital, Boston, Mass
    • Harvard Medical School, Boston, Mass
    • ,
  • Andrea S. Hale, RN, BSN, MPH

      Affiliations

    • Division of General Internal Medicine, Brigham and Women's Hospital, Boston, Mass
    • Harvard Medical School, Boston, Mass
    • ,
  • Katherine Zigmont, RN

      Affiliations

    • Division of General Internal Medicine, Brigham and Women's Hospital, Boston, Mass
    • Harvard Medical School, Boston, Mass
    • ,
  • Lisa Soleymani Lehmann, MD, PhD, MSc

      Affiliations

    • Division of General Internal Medicine, Brigham and Women's Hospital, Boston, Mass
    • Harvard Medical School, Boston, Mass
    • ,
  • James Perrin, MD

      Affiliations

    • Harvard Medical School, Boston, Mass
    • Center for Child and Adolescent Health Policy, MassGeneral Hospital for Children, Boston, Mass
    • ,
  • David W. Bates, MD, MSc

      Affiliations

    • Division of General Internal Medicine, Brigham and Women's Hospital, Boston, Mass
    • Harvard Medical School, Boston, Mass
    • Information Systems, Partners Healthcare System, Boston, Mass

Received 21 January 2007 ,Accepted 16 May 2007.

References 

  1. Institute of Medicine. To Err Is Human. Building a Safer Health System. Kohn LT, Corrigan JM, Donaldson MS, eds. Washington, DC: National Academy Press; 1999.
  2. Brennan TA, Leape LL, Laird NM, et al. Incidence of adverse events and negligence in hospitalized patients. Results of the Harvard Medical Practice Study I. N Engl J Med. 1991;324:370–376
  3. Leape LL, Brennan TA, Laird N, et al. The nature of adverse events in hospitalized patients. Results of the Harvard Medical Practice Study II. N Engl J Med. 1991;324:377–384
  4. Thomas EJ, Studdert DM, Burstin HR, et al. Incidence and types of adverse events and negligent care in Utah and Colorado. Med Care. 2000;38:261–271
  5. Bates DW, Cullen DJ, Laird N, et al. Incidence of adverse drug events and potential adverse drug events. Implications for prevention. ADE Prevention Study Group. JAMA. 1995;274:29–34
  6. Kaushal R, Bates DW, Landrigan C, et al. Medication errors and adverse drug events in pediatric inpatients. JAMA. 2001;285:2114–2120
  7. Gandhi TK, Weingart SN, Borus J, et al. Adverse drug events in ambulatory care. N Engl J Med. 2003;348:1556–1564
  8. Kaushal R, Jaggi T, Walsh K, et al. Pediatric medication errors: what do we know? What gaps remain?. Ambul Pediatr. 2004;4:73–81
  9. Walsh KE, Kaushal R, Chessare JB. How to avoid paediatric medication errors: a user's guide to the literature. Arch Dis Child. 2005;90:698–702
  10. Bates DW, Kaushal R, Keohane C, Cook EF. Center of Excellence for Patient Safety Research and Practice Terminology Training Manual. Available at: http://www.coesafety.bwh.harvard.edu/resourcesPages/Training%20Manual_V1.0.pdf. Accessed August 10, 2007.
  11. Bates DW, Leape LL, Cullen DJ, et al. Effect of computerized physician order entry and a team intervention on prevention of serious medication errors. JAMA. 1998;280:1311–1316
  12. Bates DW, Teich JM, Lee J, et al. The impact of computerized physician order entry on medication error prevention. J Am Med Inform Assoc. 1999;6:313–321
  13. McPhillips HA, Stille CJ, Smith D, et al. Potential medication dosing errors in outpatient pediatrics. J Pediatr. 2005;147:761–767
  14. Arnhold RG, Adebonojo FO, Callas ER, et al. Patients and prescriptions. Comprehension and compliance with medical instructions in a suburban pediatric practice. Clin Pediatr (Phila). 1970;9:648–651
  15. McMahon SR, Rimsza ME, Bay RC. Parents can dose liquid medication accurately. Pediatrics. 1997;100:330–333
  16. Yu SM, Huang ZJ, Schwalberg RH, Nyman RM. Parental English proficiency and children's health services access. Am J Public Health. 2006;96:1449–1455
  17. Zun LS, Sadoun T, Downey L. English-language competency of self-declared English-speaking Hispanic patients using written tests of health literacy. J Natl Med Assoc. 2006;98:912–917
  18. Nielsen-Bohlman L, Panzer A, Kindig D. Health Literacy: A Prescription to End Confusion. Washington, DC: Institute of Medicine; 2004;
  19. Kuperman GJ, Sussman A, Schneider LI, et al. Towards improving the accuracy of the clinical database: allowing outpatients to review their computerized data. Proc AMIA Symp. 1998;220–224

PII: S1530-1567(07)00090-1

doi: 10.1016/j.ambp.2007.05.005

Ambulatory Pediatrics
Volume 7, Issue 5 , Pages 383-389 , September 2007

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