Ambulatory Pediatrics
Volume 6, Issue 2 , Pages 96-99, 1 March 2006

Case-Control Confusion

  • Martha A. Hellems, MD, MS

      Affiliations

    • Department of Pediatrics, University of Virginia Children’s Hospital, Charlottesville, Va
    • Corresponding Author InformationAddress correspondence to Martha A. Hellems, Department of Pediatrics, University of Virginia, P.O. Box 800386, Charlottesville, VA 22908-0386.
    • ,
  • Michael S. Kramer, MD

      Affiliations

    • Departments of Pediatrics and Epidemiology and Biostatistics, McGill University Faculty of Medicine, Montreal, Canada
    • ,
  • Gregory F. Hayden, MD

      Affiliations

    • Department of Pediatrics, University of Virginia Children’s Hospital, Charlottesville, Va

Received 31 May 2005; accepted 27 November 2005.

Objective

Critical analysis of journal articles by using principles of evidence-based medicine is important for clinicians applying research results in their practice and is a valuable component of pediatric residency training. Appraisal of an article’s methodological rigor is often tailored to a particular type of study design, so that misclassification of study design can confuse the appraisal. The goal of this study was to determine how often pediatric research articles that are self-declared as case-control studies conform to a standard definition for this study design.

Methods

A Medline search identified articles published in two pediatric journals from January 1996 through August 2004 with the phrase “case-control study” in the title or abstract. Articles that were self-declared as case-control studies were analyzed to determine whether they satisfied a standard definition of a case-control study.

Results

Of the 91 purported case-control studies, only 68 (75%) met the standard definition for at least the most important analysis. The remaining 23 articles could be classified as cross-sectional studies (N = 16) or prospective cohort studies (N = 7).

Conclusions

Ambiguity in the definition of a case-control study can cause confusion in the critical appraisal of published clinical research.

Key words:  case-control study , study design

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PII: S1530-1567(05)00018-3

doi:10.1016/j.ambp.2005.11.001

Ambulatory Pediatrics
Volume 6, Issue 2 , Pages 96-99, 1 March 2006

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